Advanced Biomaterials and Biodevices (Advanced Materials Book Series)

Advanced biomaterials and biodevices

Ashutosh Tiwari, Anis Nurashikin Nordin

Hardcover: 576 pages   Publisher: WILEY-Scrivener,USA

Language: English        ISBN: 978-1-118-77363-5

From the Editor

Biomaterials are the most expeditiously emerging field of biodevices. Design and development of biomaterials play a significant role in the diagnosis, treatment and prevention of diseases. Recently a variety of scaffolds/carriers has been evaluated for tissue regeneration, drug delivery, sensing and imaging.  Liposomes and microspheres have been developed for sustained delivery. Several anti-cancer drugs have been successfully formulated using biomaterials. Targeting of drugs to certain physiological sites has emerged a promising tool for treatment as it improves drug efficiency and requires reduced drug dosage. Using biodevices to target drugs may improve therapeutic success through limiting the adverse drug effects, which results in better patient compliance and medication adherence. When used with highly selective and sensitive biomaterials, cutting-edge biodevices can allow rapid and accurate diagnosis of diseases; creating a platform for research and development especially in the field of treatment for prognosis and detection of diseases in the early stage. This book emphasizes on the emerging area of biomaterials and biodevices that incorporates therapeutic agents, molecular targeting and diagnostic imaging capabilities.

This book comprising of fourteen chapters in total has been divided into two major categories, Cutting edge biomaterials and Innovative biodevices. The first section, cutting edge biomaterials focuses of state of the art biomaterials such as nanostructures, smart polymers, nanoshells which can be used for medical applications. The first chapter, Frontiers for bulk nanostructured metals in biomedical applications, illustrates the usage of severe plastic deformation technique (SPD) to enhance the properties of nanostructured metals. This technique has been highly successful to augment the biomedical and mechanical properties of metals such as titanium, magnesium, cobalt and stainless steel. The second chapter, Stimuli-responsive materials used as medical devices in loading and releasing of drugs, describes the potential of different polymers to be used to control drug release. The main objective of using stimuli-responsive materials is to improve the performance of medical devices. However, the usage of these materials are still in its infancy as it is still prone to infections, inflammation and biofilm formation on surface. Chapter three, Recent advances with liposomes as drug carriers is a very interesting and comprehensive chapter which explains about artificially prepared bilayered phospolipid vesicles used as a tool for drug delivery. Significant advancement in the recent couple of decades, has improved the efficiency and solved numerous problems which exist in when using liposomes as a drug carrier. Among them are improvement in terms of the selectivity of drug carriers using engineered peptides, usage of dual-ligand combinations to reduce non-specific interactions with healthy tissues and also lowering ligand concentration using high-affinity ligands.

The chapter on Fabrication, properties of nanoshells with controllable surface charge and its applications, describes the methods used to synthesize and assemble monodispersed core-shell nanoparticles. These methods are useful to improve adsorption of CNT for ultrasensitive detection using surface enhanced Raman scattering. The chapter Advanced health care materials: Chitosan provides a review of chitin and chitosan as renewable healthcare biopolymers for biomedical applications such as wound healing or tissue regeneration, drug delivery and antimicrobial studies. The next chapter, Chitosan and low molecular weight chitosan: Biological and biomedical applications also describes chitosan’s immunological and antioxidant properties as well as its usage for treatment of tumors and viruses. The chapter Anticipating behaviour of advanced material in healthcare provides a general overview on the key aspects, which need to be considered when developing, advanced materials for healthcare applications.

Having advanced biomaterials are pointless if they cannot be used efficiently and can reach its targeted users. The next section of the book shows the reader a different point of view, it explains about Innovative devices, how they operate and how they can be used for biomedical applications. The first chapter in this section, Label-free biochips illustrates a variety of miniature bio devices, which can be used to measure different biomarkers for diseases. Unlike traditional optical imaging, the usage of mini, dye-free sensors require have the advantages of requiring less medical samples and provide noise-free measurement results. The next chapter, Polymer MEMS sensors illustrates another set of micro-electro-mechanical systems (MEMS) sensors that are based on cantilevers. These miniature cantilevers can convert biological signals into different electrical signals (current, resistance and voltage).

The next chapters move away from describing devices to illustrating state-of-the-art techniques to improve devices. Assembly of polymers or metal nanoparticles and their applications as medical devices demonstrate the usage of polymer covered metal nanoparticles in medical devices. Polymer-metal nanoparticles are favored due to their low toxicity, antibacterial and antiviral properties. MEMS technologies often employ the top-down approach to build their devices. An emerging bottom-up technique uses nanostructures to form building blocks of the devices. The chapter Combination of molecular imprinting and nanotechnology: Beginning of a new horizon, explains this new concept and its advantages such as enzyme-like and antibody-like properties, small physical size, solubility, flexibility and recognition site accessibility. The next chapter, Prussian blue and analogues: Biosensing applications in health care, educates the readers on why Prussian Blue, a transitional metal is very popular in biosensing applications recently. The chapter Efficiency of biosensor as new generation of analytical approaches at the biochemical diagnostics of diseases evaluates different types of biosensors (electrochemical, optical) in terms of its cost effectiveness, selectivity and sensitivity. Nanoparticles: Scope in drug delivery illustrates the usage of nanoparticles (solid lipid, polymeric, liposomes, mesoporous silica) for drug-targeting to improve the efficiency of drug delivery in humans. Better drug efficacy is especially important in hazardous diseases such as cancer, which still uses toxic drugs for treatment. While having numerous advantages such as reduced dosage frequencies, versatile administration methods, better disease management, it is still too soon to know the long term effects of these nanoparticles on humans and the environment. The final chapter, Smart polypeptide nanocarriers for malignancy therapeutics reviews the recent advances in stimuli-responsive polypeptide nanocarriers for malignancy therapeutics.

Given the diversity of topics covered in this book, it can be read both by university students and researchers from various backgrounds such as chemistry, materials science, physics, pharmacy, medical science, and biomedical engineering. The interdisciplinary nature of its chapters and simple tutorial nature makes it suitable as a textbook for both undergraduate and graduate students, and as a reference book for researchers seeking an overview in the state-of-the-art biomaterials and devices used in biomedical applications. We hope that chapters of this book will give its readers’ valuable insight and alternative mechanisms in the field of advanced materials and innovative biodevices.

Overall, the book has been a very interesting read. The author has managed to explain and demystify the complex topic of neuroscience research using very clear and simple language. The best part about the book is that it does not require specific background knowledge of the topic, making it easy for readers of different disciplines to understand the operating principles and key design criteria for a neuro sensor. We would highly recommend the book for scientists that wish to start their research in the field of neuroscience, or for experienced neuroscientists that wish to explore alternative mechanisms for their sensors. Although, the book is written for readers from diverse backgrounds across chemistry, physics, materials science and engineering, medical science, pharmacy, biotechnology, and biomedical engineering. It offers a comprehensive view of cutting-edge research on advanced materials for healthcare technology and applications.

Description of Book-

Chapter 1

Cyclodextrins as advanced materials for pharmaceutical applications

Ivan Savic, Serbia

Chapter 2

Implantable materials for local drug delivery in bone regeneration

Mariana Landin Perez, Spain

Chapter 3

Assembly of polymers/metal nanoparticles and their applications in medical devices

Magdalena M. Stevanovic, Russia

Chapter 4

Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane for new and emerging biomedical applications

Peter Chang, Canada

Chapter 5

Multi-scale modelling and X-ray diffraction characterization of elastic behaviour of human dental tissue

Alexander Korsunsky, UK

Chapter 6

Biodegradable porous hydrogels

Martin Hruby, Czech

Chapter 7

Polyhydroxyalkanoate-based biomaterials for tissue engineering

Qizhi Chen, Australia

About the author

VBRI Group is an innovative and ambitious organization started by Dr. Ashutosh Tiwari (Chairman and managing director).
VBRI group majorly deals with research, technology and innovation. The technology developed and adopted here is for the betterment of rural area and deals with the issues related to agriculture, health and education. It’s a group of companies, comprises VBRI Foundation, VBRI Education, VBRI Events, VBRI Press and VBRI Technology.

The group-business has witnessed expansion in various domain by providing appropriate solution and consultancy through world class platform.

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