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DNA Engineered Noble Metal Nanoparticles: Fundamentals and State-of-the-Art of Nanobiotechnology

DNA Engineered Noble Metal Nanoparticles: Fundamentals and State-of-the-Art of NanobiotechnologyIgnác Capek, Ashutosh Tiwari (Series Editor)

Hardcover: 672 pages   Publisher: WILEY-


Language: English        ISBN: 978-1-118-07214-1




From the Editors-

There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and therefore they are attractive materials for nanotechnology in biochemistry and medicine.

 In this book, the author review work performed dealing with the DNA structure and functionalities, interactions between DNA, noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA’s chain length and the DNA conformation affect the interaction and structure of the Nano conjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and, mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, this book reviews recent progress in the area of DNA-noble metal nanoparticles based artificial nanostructures, that is, the preparation, collective properties, and applications of various DNA-based nanostructures are also described.

Book Description

Chapter 1


Chapter 2

Nucleic Acids

Chapter 3

Noble Metal Nanoparticles

Chapter 4

DNA-Based Conjugates

Chapter 5

DNA-Noble Metal Nanoparticle Conjugates

Chapter 6

DNA-Gold Nanoparticle Conjugates

Chapter 7

PNA-Noble Metal Nanoparticles Conjugates

Chapter 8

DNA-Silver Nanoparticles Conjugates

Chapter 9

The Structure of DNA-Noble Metal Nanoparticles Conjugates

Chapter 10

Photochemical and Photophysical Events

Chapter 11

Nanoparticle Therapeutics

Ashutosh Tiwari is Chairman & Managing Director at Institute of Advanced Materials & VBRI Group, Secretary General of the International Association of Advanced Materials and Editor-in-Chief of Advanced Materials Letters. Dr. Tiwari also has several adjuncts and honorary professor titles since 2009. Professor Ashutosh Tiwari has been actively involved in the translational research for building state-of-the-art technological systems to handle key challenges in medical, security, energy supply and environmental issues realized by the integration of artificial intelligence and smart strategies. Currently, Ashutosh works mainly on the technological developments of the range of nanotechnology-enabled new tools, technological breakthroughs, key process, new products designed to transform the energy, IT automation, security, and mass medicine.

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