Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

Ashutosh Tiwari, Atul Tiwari

Hardcover:576 pages   Publisher: WILEY Scrivener,USA

Language: English        ISBN: 978-1-118-29032-3

From the Editors-

The ability to control the structure of materials has geared scientists to accomplish the developments that appeared impossible without advent of nanotechnology. It is currently auspicious to generate nanoscopic self-assembled and self-destructive robots that could be effectively utilized in therapeutics, diagnosis and biomedical implants.

Theareputic drugs could be encapsulated in precisely fabricated lipid based nanocarriers for the use in imaging and drug delivery. The chapter on nanoemulsions: preparation, stability and application in biosciences describe the application of such techniques in pharmaceuticals and cosmetic industry. The available synthetic routes help in developing polymeric materials that can potentially be used for biomedical applications. The chapter tiled multifunctional polymeric nanostructures for therapy and diagnosis describes the fabrication of tuneable polymers by conventional chemical methods and sophisticated processes such as surface modification using ionizing radiation. Such synthetic materials are often associated with the toxic side effects that needs to be regulated. The chapter on carbon nanotubes: nanotoxicity testing and bioapplications investigates the cytoxicity and inflammatory responses of such engineered nanomaterials. An overview of novel metalla-assemblies as drug carriers is presented in chapter discrete metalla-assemblies as drug delivery vectors. The notable advantages and limitations of metalla-assemblies from biological point of view are apprehended.

A thrust towards the development of novel nanoparticles paved the way for sucessful cancer diagnosis and treatment. The gene therapy for curing multiple inherited and/or acquired diseases has become an active area of research and development. In chapter nano-sized calcium phosphate carriers for non-viral gene/drug deilvery, the bioceramics has been investigated as a vehicluar media for the gene delivery. A dedicated chapter on nanomaterials for management of lung disorders and drug delivery summarizes different types of nanoparticles currently available for pulmonary drug delivery. This chapter also discusses various mechanism and challenges in inhalational drug delivery technologies. The mesoporpous silica as stimuli responsive drug delivery vehicle has been detailed in chapter organics modified mesoporous silica for controlled drug delivery systems. Similar attempts have been made in chapter inorganic nanoparticle materials for controlled drug delivery systems. A chapter on theranostic nanoparticles for cancer imaging and therapy presents recent progress, advantages and limitations in the development of nanoparticles for cancer theranostics. An analysis of recent advances on the responsive polymer-inorganic hybrid nanogels is provided in chapter titled responsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery.

The nanoparticle fabrication techniques that produce hydrophilic core/shell and can incorporate hydrophobic drugs offer considerable advantages for diagnosis and therapy. A chapter on core/shell nanoparticles for drug delivery and diagnosis focuses on nanomedicine for tumor targeting stimulated release of proteins, and cancer imaging capabilities. Dendrimetric network polymer nanoparticles on the other hand offer certain advantages that are not available in other materials. The high surface functionalities available in such materials provide opportunity to modify its outer surface and achieve multivalent effects. A chapter on dendrimer nanoparticles and their applications in biomedicine explores the unique features of this nanomaterial for successful future applications as biotherapeutics.

The biocompatible polymeric architect is gaining significant attention in scaffolds for tissue regeneration, tissue adhesives, hemostats, and transient barriers for tissue adhesion. A chapter on nanostructure polymers in function generating substitute and organ transplants highlights various nanoengineerd polymeric materials that are being utilized in function generating substitutes and organ transplants. Similarly, nanofibrous scaffolds are widly studied for the tissue engineering. The chapter on electrospun nanofiber for three dimensional cell culture describes the fabrication and interesting properties of electrospun nanofiber matrices. Another chapter on core-sheath fibers for regenerative medicine discusses the fabrication of core-sheath nanofibers and its application in regenerative medicine. The use of magnetic particles is gaining momentum toward its use in three dimentional tissue generation. The final chapter on magnetic nanoparticles in tissue regeneration gives an overview on the progress of magnetic nanoparticles for cell directed tissue engineering and regenerative medicine.

The book is written for a large readership including university students and researchers from diverse backgrounds such as chemistry, materials science, physics, pharmacy, medical science, and biomedical engineering. It can be used not only as a textbook for both undergraduate and graduate students, but also as a review and reference book for researchers in the materials science, bioengineering, medical, pharmacy, biotechnology and nanotechnology. We hope that chapters of this book will give a valuable insight in the major area of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics and cutting-edge nanoscaffolds to the readers. The interdisciplinary nature of the topics in this book will help young researchers and senior academicians. We are grateful to Martin Scrivener for giving us the opportunity to edit this book on a subject of high scientific curiosity and importance.

Description of Book-

Biomedical nanomaterials

Chapter 1

Nanoemulsions: preparation, stability and application in biosciences

Jérôme Bibette, France

Chapter 2

Multifunctional polymeric nanostructures for therapy and diagnosis

Emilio Bucio, México

Chapter 3

Carbon nanotubes: Nanotoxicity testing and bio-applications

Sharma, S. Kwon, USA

Advanced nanomedicine

Chapter 4

Discrete metalla-assemblies as drug delivery vectors

Bruno Therrien, Switzerland

Chapter 5

Nanomaterials for management of lung disorders and drug delivery

Kytai T. Nguyen, USA

Chapter 6

Nano-sized calcium phosphate (CaP) carriers for non-viral gene delivery

Donghyun Lee, South Korea

Chapter 7

Organics modified mesoporous silica for controlled drug release systems

Yingchun Zhu, China


Chapter 8

Responsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery

Shuiqin Zhou, USA

Chapter 9

Core/shell nanoparticles for drug delivery and diagnosis

Soon Hong Yuk, Republic of Korea

Chapter 10

Dendrimer nanoparticles and their applications in biomedicine

Satya Prakash, Canada

Chapter 11

Theranostic polymeric nanoparticles for enhanced cancer therapy

Shyh-Dar Li, Canada

Nanoscaffolds technology

Chapter 12

Nanostructure polymers in function generating substitute and organ transplants

K. Shukla, India

Chapter 13

Electrospun nanofibers for three dimensional cell cultures

Ashutosh Tiwari, Sweden

Chapter 14

Magnetic nanoparticles in tissue regeneration

Anuj Tripathi, India

Chapter 15

Core-sheath fibres for regenerative medicine

Rajesh Vasita , Fabrizio Gelain, Italy

About the author

VBRI Group is an innovative and ambitious organization started by Dr. Ashutosh Tiwari (Chairman and managing director).
VBRI group majorly deals with research, technology and innovation. The technology developed and adopted here is for the betterment of rural area and deals with the issues related to agriculture, health and education. It’s a group of companies, comprises VBRI Foundation, VBRI Education, VBRI Events, VBRI Press and VBRI Technology.

The group-business has witnessed expansion in various domain by providing appropriate solution and consultancy through world class platform.

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